.

.

Abstract:

The present study concentrated on samples of Libyan dates procured from the markets in Gharyan City. A series of qualitative analyses were conducted in order to assess the content of their active ingredient, with a particular focus on antioxidants. The qualitative identification of tannins, flavonoids, glycosides, saponins, and resins (utilised as tanning agents) was conducted utilising standard reagents such as Dragendorff's, Fehling's, and Benedict's, in conjunction with date extracts. The analyses confirmed the presence of all these compounds in the samples. Furthermore, quantitative assessments of the fundamental components of the date samples were conducted. The procedure entailed the quantification of fibre, carbohydrates, protein, fat, and ash content. Furthermore, the moisture content and the ratio of pits to fruit were evaluated in all samples. The assessment employed a kiln, a Kjeldahl apparatus, and other requisite equipment to determine the caloric values of each sample. The findings indicated variations in the fundamental components and energy content among the samples, likely attributable to various factors and conditions.

Keywords: Dates, antioxidants, free radicals, plant active ingredients

This study presents a strategic synthetic approach to functionalize the traditionally unreactive C3 position of the benzothiophene core. A series of 3-chloro-N-(aryl)benzothiophene-2-carboxamides (2a–d) were synthesized in good to excellent yields (53–83%) via amidation of 3-chloro-2-chlorocarbonylbenzothiophene[b]thiophene (1).Subsequent oxidation with hydrogen peroxide in acetic acid afforded the corresponding sulfone derivatives (3a–d), a transformation that reduced aromaticity and activated the C3 position. This activation enabled anucleophilic aromatic substitution, where chlorine in sulfone 3b was replaced by ethylamine, isopropylamine, and diethylamine, yielding novel 3-aminobenzothiophene-1,1-dioxides (4a–c) in moderate yields (50–64%). All new compounds were fully characterized by IR, ¹H NMR, and ¹³C NMR spectroscopy. The synthesized derivatives were evaluated in vitro for antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and fungal strains (Candida albicans, Crysosporium pannical, Aspergillus niger, Rhizopus oryzae). While overall activities were slight to moderate compared with standard drugs, compounds 3a and 3b displayed a promising broad-spectrum profile. These findings establish an efficient and versatile methodology for accessing C3-functionalized benzothiophenes, providing a valuable foundation for the design of new lead structures against resistant microbes.

This study integrates compliance evaluations and organic solvent risk assessments to enhance laboratory safety in Gharyan University chemistry laboratories. Six laboratories (Analytical, Biochemistry, Organic, Physical, Inorganic, and Research) were assessed for safety compliance across five elements: storage, PPE, usage areas, emergency management, and documentation. Concurrently, a systematic risk assessment was performed for seven common organic solvents (ether, chloroform, benzene, methanol, hexane, acetone, and ethanol), considering inherent hazard severity and laboratory-specific probability. Results showed moderate overall compliance (26.09%-38.26%), with the organic laboratory exhibiting the highest. "Emergency Management" was a universal weakness (20.00% compliance). Risk assessment revealed 62.5% of solvent-laboratory combinations posed very high risks, with ether, chloroform, and benzene consistently hazardous. A clear link emerged between laboratory compliance and risk profiles; higher compliance correlated with lower solvent risks. This research provides empirical evidence that improved safety compliance mitigates risks, offering a novel framework for integrated safety assessment in academic settings. Findings emphasize strengthening safety management, particularly in emergency preparedness and PPE use, to reduce risks from organic solvents in university chemistry laboratories. Keywords: organic solvents, risk assessment, compliance analysis, chemical hazards, safety management.

.

Synthesizing silver nanoparticles (AgNPs) from extracts of various plant parts

and of agricultural waste is strongly affected by pH. These green synthesis

methods cconsidered simple, cost effective, ecofriendly, and biologically

effective. This brief review aimed to survey the role of pH in the green

synthesis of AgNPs using those media, with a focus on its effect on AgNPs

morphology and size. This review article revealed that the alkaline pH (9 -

10) is the optimum condition for synthesizing more stable and tiny uniform

AgNPs. In addition, according to the reviewed articles, the spherical shape is

the most dominant shape of these articles in the basic medium and the size of

these particles decreases at elevated pH values and ranged from 5-40 nm

Synthesizing silver nanoparticles (AgNPs) from extracts of various plant parts

and of agricultural waste is strongly affected by pH. These green synthesis

methods cconsidered simple, cost effective, ecofriendly, and biologically

effective. This brief review aimed to survey the role of pH in the green

synthesis of AgNPs using those media, with a focus on its effect on AgNPs

morphology and size. This review article revealed that the alkaline pH (9 -

10) is the optimum condition for synthesizing more stable and tiny uniform

AgNPs. In addition, according to the reviewed articles, the spherical shape is

the most dominant shape of these articles in the basic medium and the size of

these particles decreases at elevated pH values and ranged from 5-40 nm.

Heavy metals can be released from cooking stewpots into food, causing food contamination and posing a risk to human health. This research study investigated the release of heavy metals into food from stewpot cookers used in Gharyan, Libya. As well as, investigating the effect of scratches, acidic food, and storage on the concentrations of those metals. Eight new and used cooking stewpots (with scratches) made of: (Tefal, stainless steel, copper and aluminum) were collected, and then fresh tomato juice was cooked in these stewpots and left in the refrigerator for six days, the samples were digested and analyzed by atomic absorption spectrophotometer (AAS) to measure the concentration of the heavy metals: (cadmium, lead, iron, copper and zinc). Results showed that cadmium and lead concentrations were less than the detection limit of the AAS instrument, except for one sample (old Tefal stewpot with scratches), in which the lead concentration was (0.046ppm). The concentration of iron, copper and zinc in the samples was less than the maximum limit allowed by WHO/FAO; except for one sample in which the iron concentration exceeded that value (old copper pot with scratches) and its value was (2.892ppm). The results of the descriptive statistical analysis showed that the average concentration of iron (0.493 ppm) was higher than that of zinc and copper (0.054 ppm), (0.016 ppm), respectively. In addition, the rate of leakage of those elements from old (scratched) cookware was higher than that from the new ones made from the same material, and the concentration of these elements increases significantly when these stewpots contain scratches, since that increases the rate of leakage of those metals, especially in acidic food such as tomatoes.